FSCN1 is an actin-bundling protein that is responsible for rigidity to filopodial bundles to efficiently push the membrane forward during cytoskeleton remodeling and cell migration. FSCN1 takes part in the gathering of actin filament bundles present in microspikes， membrane ruffles， and stress fibers. FSCN1 is absent from most normal epithelia though is upregulated in multiple forms of human carcinoma， where its expression associates clinically with a poor prognosis. FSCN1 expression is abundantly found in neurons， glial cells， and endothelial cells.
