MLH1 is an 87kDa protein involved in mismatched nucleotides during DNA replication or repair process. Mutations in the human MLH1 （hMLH1） and hMLH2 genes contribute to the development of sporadic colorectal carcinoma and some other both hereditary and sporadic forms of human cancer.
MLH1 is identified as a locus frequently mutated in hereditary nonpolyposis colon cancer （HNPCC）. MLH1 is a human homolog of the E. coli DNA mismatch repair gene mutL， consistent with the characteristic modifications in microsatellite sequences （RER+ phenotype） found in HNPCC.
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大肠杆菌中重组表达
溶解建议
Sterile Filtered clear solution. The MLH1 at 100ug/ml in 50mM Tris-Acetate， pH7.5， 1mM EDTA and 20% Glycerol.
保存建议
Store vial at -20℃ to -80℃. When stored at the recommended temperature， this protein is stable for 12 months.
Please prevent freeze-thaw cycles.
