Vimentin expression in human malignant glioma cells depends on cellular density， algorithms of drug delivery and chemo/radio treatment. Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. Primary colorectal carcinomas display aberrant expression of vimentin， and have activated Notch and TGFbeta signaling pathways. Vimentin is a strong arterial substrate for transglutaminases. Transglutaminase-mediated vimentin dimerization results in a novel unifying pathway by which vasodilatory and remodeling responses may be regulated. Ablation of vimentin expression inhibits migration and invasion of colon and breast cancer cell lines. Vimentin is the main intermediate filament protein in mesenchymal cells and is therefore of value in the differential diagnosis of undifferentiated neoplasms.
序列
请咨询我们客服或者请查看品牌官方网站
来源宿主
牛晶状体组织中提取纯化
溶解建议
Sterile Filtered White lyophilized （freeze-dried） powder. The protein （1mg/ml） was lyophilized from a 1mg/ml solution containing 10mM sodium phosphate pH 7.5， 6M urea， 2mM DTT， 1mM EDTA and 10mM methylammonium chloride.It is recommended to reconstitute the Bovine Vimentin in sterile 18MΩ-cm H2O not less than 100ug/ml， which can then be further diluted to other aqueous solutions.
保存建议
It is recommended to reconstitute the Bovine Vimentin in sterile 18MΩ-cm H2O not less than 100ug/ml， which can then be further diluted to other aqueous solutions.
