ACTN1 encodes a nonmuscle， cytoskeletal， alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins， including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells， the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions， where it is involved in binding actin to the membrane. In contrast， skeletal， cardiac， and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies， where they help anchor the myofibrillar actin filaments.
序列
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来源宿主
鸡胗组织中提取纯化
溶解建议
Sterile Filtered White lyophilized （freeze-dried） powder. The protein was lyophilized from a 1mg/ml solution containing 10mM Tris acetate buffer pH 7.6， 0.1mM EDTA， 2mM DTT， and 20mM NaCl. It is recommended to reconstitute the lyophilized a-Actinin in sterile 18MΩ-cm H2O not less than 100ug/ml， which can then be further diluted to other aqueous solutions.
保存建议
Lyophilized a-Actinin although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution a-Actinin should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
