Filaggrins are an important class of the intermediate filament-associated proteins which interact with keratin intermediate filaments （Ifs） of terminally differentiating mammalian epidermis. Filaggrins exhibit wide species variations. Filaggrin also appears to be a target molecule for rheumatoid arthritis-specific auto-antibodies in humans. Profilaggrin is a key protein component of the keratohyalin granules of mammalian epidermis. It is primarily expressed as a large polyprotein precursor which is later proteolytically processed into individual functional filaggrin molecules. Persons with truncation mutations in the filaggrin gene， are strongly predisposed to a severe form of dry skin， （ichthyosis vulgaris）， and/or eczema. It was shown that approximately 50% of all severe cases of eczema may have at least one mutated filaggrin gene. Truncation mutations R501X and 2284del4 are the most widespread mutations in the caucasian population， with 7-10% of the caucasian population carrying at least one copy of these mutations. R501X and 2284del4 are not usually found in non-caucasian individuals， nevertheless novel mutations （3321delA and S2554X） have been found in Japanese populations that yield similar effects.
序列
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered clear solution. Filaggrin in 50mM Tris-Acetate， pH7.5， 1mM EDTA and 20% Glycerol.
保存建议
Store vial at -20℃ to -80℃. When stored at the recommended temperature， this protein is stable for 12 months.
Please prevent freeze-thaw cycles.
