Chromatin modifying protein 2A （CHMP2A） is a member of the SNF7 family and it is a component of the ESCRT III complex， which is required for MVBs （multivesicular bodies） formation and sorting of endosomal cargo proteins into MVBs.
The MVB pathway mediates release of transmembrane proteins into the lumen of the lysosome for degradation. The MVB pathway requires the sequential function of ESCRT-O， -I，-II and -III complexes. ESCRT-III proteins generally detach from the invaginating membrane before the ILV （intraluminal vesicles） is released. ESCRT-III proteins are thought to mediate the basic vesicle extrusion and/or membrane fission activities， probably in conjunction with the AAA ATPase VPS4.
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大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The CHMP2A solution contains 20mM Tris-HCl buffer （pH8.0） ， 0.1M NaCl 1mM DTT， and 30% glycerol.
保存建议
CHMP2A although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
