The Bcl-2 family of protein is characterized by its ability to modulate cell death under a broad range of physiologic conditions. Bcl-2 and several related proteins function to inhibit apoptosis while other members of the Bcl-2 family， such as Bax and Bak， enhance cell death under various conditions. Bad exhibits homology to Bcl-2 limited to the BH1， but not with Bax， Bcl-xS， Mcl-1， A1 or itself. In mammalian cells， Bad binds with greater affinity to Bcl-xL than to Bcl-2 and reverses the death repressor activity of Bcl-xL but not Bcl-2.
序列
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered clear solution. BAD protein in 50mM Tris-Acetate， pH7.5， 1mM EDTA， 20% Glycerol.
保存建议
Store vial at -20℃ to -80℃. When stored at the recommended temperature， this protein is stable for 12 months.
Please prevent freeze-thaw cycles.
