The retinoid X receptor （RXR） is a pleiotropic nuclear receptor transcription factor that interacts with a variety of nuclear receptor dimeric partner. RXR binds cognate response elements as a homodimer in the presence of its ligand， 9-cis retinoic acid， or as a heterodimer with other members of the nuclear hormone receptor superfamily including retinoic acid receptors （RAR）， thyroid hormone receptors （TR）， vitamin D receptors and peroxisome proliferators-activated receptors （PPAR）. The RXR family includes three different isoforms； RXR a， b， g . Human RXR a gene is localized on 9q34.9 and encodes two major isoforms （RXR a1， RXR a2）. The DNA binding domain of RXR （111-228aa） was purified by using conventional column chromatography techniques.
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大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. The protein containing 20mM Tris-HCl pH7.5， 0.1M NaCl， 5mM b-Mercaptoethanol.
保存建议
Store at 4℃ if entire vial will be used within 2-4 weeks.
Store， frozen at -20℃ for longer periods of time.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Avoid multiple freeze-thaw cycles.
