CCAAT/enhancer binding protein（C/EBP） a is a family of transcription factors that all contain a highly conserved， basic-leucine zipper domain at the C-terminus that is involved in dimerization and DNA binding. C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP family consist of several related proteins， C/EBP a，b，g，d， that form homodimers and that form heterodimers with each other. C/EBP proteins contain the bZIP region， which is characterized by two motifs in the C-terminal half of the protein； a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. C/EBPs differ significantly in their physiological functions and in their downstream target genes. For example， mice lacking C/EBPa die shortly after birth due to severe hypoglycemia and the absence of glycogen storage in liver， whereas knockout of C/EBPb causes defects in female reproduction.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. The protein contains 20mM Tris-HCl pH7.5， 0.1M NaCl and 5mM b-Mercaptoethanol.
保存建议
Store at 4℃ if entire vial will be used within 2-4 weeks.
Store， frozen at -20℃ for longer periods of time.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Avoid multiple freeze-thaw cycles.
