Bcl-2–associated X protein （Bax） belongs to the Bcl-2 protein family. Bax is a pro-apoptotic Bcl-2 protein containing BH1， BH2 and BH3 domains. Bax accelerates programmed cell death by binding to， and antagonizing the apoptosis repressor bcl2 or its adenovirus homolog e1b 19k protein. Bax induces the release of cytochrome c， activation of casp3， and thereby apoptosis. Bax is expressed in a wide variety of tissues， with highest levels in the testis and ovary. Tumor suppressor protein p53 upregulates the expression of BAX. Bax has been shown to be involved in p53-mediated apoptosis.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The protein contains 10mM Tris-HCL pH-8， 1mM EDTA and 250mM NaCl.
保存建议
Mouse Bax although stable at 12℃ for 1 week， should be stored desiccated below -18℃.
Please prevent freeze-thaw cycles.
