The ribosomal phosphoproteins， also called P protein antigens， are associated with the large ribosomal subunit and therefore are antigenic targets with a cytoplasmic localization. Three P proteins have been described: P0 with a molecular weight of 35 kDa， P1 （19 kDa） and P2 （17 kDa）. RPLP0 is a ribosomal protein that is a component of the 60S subunit. RPLP0 belongs to the L10P family of ribosomal proteins. RPLP0 is a neutral phosphoprotein having a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 & P2. The P0 protein interacts with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers， and a P0 monomer. As is typical for genes encoding ribosomal proteins， there are multiple processed pseudogenes of RPLP0 scattered throughout the genome.
Autoantibodies against ribosomal P proteins are present in 10 % of SLE patients. If anti-ribosomal P antibodies were to occur in the absence of other typical SLE associated autoantibodies， they may account for some patients with so-called ANA-negative lupus. It has been reported that lupus patients positive for anti-ribosomal P autoantibodies have a high frequency of CNS involvement， suggesting a marker use for these antibodies.
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昆虫Sf9细胞中重组表达
溶解建议
RPLP0 is supplied in 20mM HEPES buffer pH-7.5， 0.01mM EDTA & 0.02% SDS.
保存建议
Store at 4℃ if entire vial will be used within 2-4 weeks.
Store， frozen at -20℃ for longer periods of time.
Avoid multiple freeze-thaw cycles.
