Centromere proteins are a group of proteins which form and/or mediate the function of centromeres， the central structures of chromosomes to which spindle fibers/microtubuli attach and pull the chromosomes apart in cell division. Currently， 9 centromere proteins are known and designated CENPA to CENP-I. Most of the centromere proteins are targets of autoantibodies， the anti-centromere antibodies.
CENPB is the most important of the centromeric autoantigens: it has a molecular weight of approx. 66 kDa and plays an important role in the formation of the centromeric chromatin. CENPB antibodies are present in the sera of up to 80% of patients with CREST syndrome.
序列
请咨询我们客服或者请查看品牌官方网站
来源宿主
昆虫Sf9细胞中重组表达
溶解建议
Sterile Filtered liquid formulation. CENPB is supplied in 20mM HEPES buffer pH-7.6， 250mM sodium chloride， and 20% glycerol.
保存建议
Store at 4℃ if entire vial will be used within 2-4 weeks.
Store， frozen at -20℃ for longer periods of time.
Avoid multiple freeze-thaw cycles.
