ICAM-1 also called CD54 is a single chain membrane glycoprotein expressed on the surface of a variety of non-haematopoietic and haematopoietic cell types and has roles in signal transduction， cell signaling and lymphocyte adhesion. ICAM1 binds to integrins such as CD11a / CD18， or CD11b / CD18. ICAM1 is also used by Rhinovirus as a receptor. ICAM-1 is an intercellular adhesion molecule constantly present in low concentrations in the membranes of leukocytes and endothelial cells. When stimulated by cytokine the concentrations significantly increase. ICAM-1 can be stimulated by interleukin-1 （IL-1） and tumor necrosis factor alpha （TNF?） and is expressed by the vascular endothelium， macrophages and lymphocytes. ICAM-1 is a ligand for LFA-1 which is a receptor found on leukocytes. Upon activation， leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues.
ICAM-1 is implicated in subarachnoid hemorrhage （SAH）. Levels of ICAM-1 are shown to be notably elevated in patients with SAH.
Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory conditions.
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大肠杆菌中重组表达
溶解建议
Sterile Filtered clear solution. ICAM-1 is supplied （0.2mg/ml） in PBS， 50% Glycerol， 2mM Imidazole.
保存建议
Store at 4℃ if entire vial will be used within 1-2 weeks.
Store， frozen at -20℃ for longer periods of time.
Avoid multiple freeze-thaw cycles.
