L-Selectin belongs to a family of divalent cation-dependent carbohydrate-binding glycoproteins or adhesion molecules. The L-Selectin molecule is composed of various domains: one homologous to lectins， one to epidermal growth factor， and two to the consensus repeat units found in C3/C4 binding proteins.
L-selectin is expressed constitutively on lymphocytes， monocytes and granulocytes and interacts specifically with carbohydrate groups on activated endothelial cells. L-Selectin may be shed by proteolytic cleavage and circulating levels in biological fluids may be used as an indicator of various pathological conditions. L-Selectin is cleaved by ADAM17.
L-selectin works as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via the high endothelial venules. Ligands present on endothelial cells will attach to leukocytes expressing L-selectin， which causes the leukocytes to become localized at that juncture. The receptor is also located on the cell surfaces of "naive" T cells， which have not yet encountered their particular antigen. This surface expression is lost following the cells activation.
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大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. L-Sel is supplied in 1x PBS and 50% Glycerol.
保存建议
Store at 4℃ if entire vial will be used within 1-2 weeks.
Store， frozen at -20℃ for longer periods of time.
Avoid multiple freeze-thaw cycles.
