Intrinsic Facor is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12 in the terminal ileum. Vitamin B12 is essential for erythrocyte maturation and mutations in the Intrinsic Facor may lead to congenital pernicious anemia. Upon entry into the stomach， vitamin B12 binds to one of two B12 binding proteins present in the gastric fluid. In the less acidic environment of the small intestine， these proteins dissociate from the vitamin， allowing it to bind to intrinsic factor and enter the portal circulation through a receptor in the ileal mucosa specific for the B12-intrinsic factor complex.
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来源宿主
昆虫Sf9细胞中重组表达
溶解建议
Sterile Filtered colorless solution. The protein solution （0.7mg/ml） contains 20mM HEPES pH-8， 100mM NaCl， 20% Glycerol.
保存建议
IF although stable at 10℃ for 1 week， should be stored desiccated below -18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
