MICA （MHC class I chain-related gene A） is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein， MICB， shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig-like domains， but they have no capacity to bind peptide or interact with ?2-microglobulin. The genes encoding these proteins are found within the Major Histocompatibility Complex on human chromosome 6. The MICA locus is highly polymorphic with more than 50 recognized human alleles. MICA is absent from most cells but is frequently expressed in epithelial tumors and can be induced by bacterial and viral infections. MICA is a ligand for human NKG2D， an activating receptor expressed on NK cells， NKT cells， ? ? T cells， and CD8+ ? ? T cells. Recognition of MICA by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA recognition is involved in tumor surveillance， viral infections， and autoimmune diseases.
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大肠杆菌中重组表达
溶解建议
Sterile Filtered White lyophilized （freeze-dried） powder. Lyophilized from a concentrated （1mg/ml） solution containing no additives. It is recommended to reconstitute the lyophilized MICA in sterile 18MΩ-cm H2O not less than 100ug/ml， which can then be further diluted to other aqueous solutions.
保存建议
Lyophilized MICA although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution MICA should be stored at 4℃ between 2-7 days and for future use below
-18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
