S100A1 is a member of the S100 family of calcium binding proteins with EF-hand type Ca+2 binding motive. S100A1 （Calcium Binding Protein A1） is involved in the activation of sarcoplasmatic calcium release and the regulation of intermediate filament polymerization. S100A1 may function in stimulation of Ca2+-induced Ca2+ release， inhibition of microtubule assembly， and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of S100A1 has been implicated in cardiomyopathies.
S100 proteins are localized either in the cytoplasm or the nucleus of a wide range of cells. There are at least 13 members in the S100 gene family， which are located as a cluster on chromosome 1q21.
序列
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered clear solution. S100A1 in 20mM Tris-HCl， pH7.0 and 0.1mM EDTA.
保存建议
Store vial at -20℃ to -80℃. When stored at the recommended temperature， this protein is stable for 12 months.
Please prevent freeze-thaw cycles.
