PFDN1 is one of 6 subunits of prefoldin， which is a heterohexameric chaperone protein that assists in the proper folding of other proteins. The PFDN1 protein delivers nonnative target proteins， primarily actins and tubulins， to the eukaryotic cytosolic chaperonin for facilitated folding. Defects in PFDN1 presented phenotypes typical of defects in cytoskeletal function， including manifestations of ciliary dyskinesia， neuronal loss， and defects in B and T cell development and function.
