Cullin1， is an essential component of multiple cullin-RING-based SCF （SKP1-CUL1-F-box protein） E3 ubiquitin-protein ligase complexes， that facilitate the ubiquitination of proteins which take part in cell cycle progression， signal transduction and transcription. In the SCF complex. Cullin1 assists in a rigid scaffold which organizes the SKP1-F-box protein and RBX1 subunits. Cullin1 contributes to catalysis by positioning of the substrate and the ubiquitin-conjugating enzyme.
