Sorting nexin 3 （SNX3） belongs to the large family of hydrophilic proteins， which interact with various receptor types and are involved in intracellular trafficking. SNX3 interacts with phosphatidylinositol-3-phosphate， and is involved in protein trafficking. SNX3 comprises a distinct subgroup of nexins， which share less sequence similarity outside of the PX domain and have significantly different binding affinities for the tyrosine kinase receptors.
