Toll interacting protein （TOLLIP） is an inhibitory adaptor protein within Toll-like receptors. The TLR pathway is a part of the innate immune system which recognizes structurally conserved molecular patterns of microbial pathogens， initiating an inflammatory immune response. Negative regulation of TLR signaling by TOLLIP might restrict the production of proinflammatory mediators during inflammation and infection. Furthermore， TOLLIP forms a complex with Tom1 to regulate endosomal transferring of ubiquitinated proteins.
