Eukaryotic translation elongation factor 1 epsilon-1 （EEF1E1） shares sequence similarity with the amino-terminal ends of the Beta and Gamma subunits of EF-1. By specifically interacting with MetRS， EEF1E1 binds to a macromolecular tRNA synthtase complex which catalyzes the ligation of specific amino acids to their cognate tRNAs. Upon DNA damage， EEF1E1 translocates to the nucleus where it interacts with ATM and ATR， resulting in p53 activation.
