Chloride intracellular channel 4 （CLIC4） belongs to the p64 family； CLIC4 is expressed in various tissues and exhibits an intracellular vesicular pattern in Panc-1 cells （pancreatic cancer cells）. CLIC4 is a 253 amino acid single-pass membrane protein which localizes to both the nucleus and the cytoplasm and contains one GST C-terminal domain. CLIC4 acts as a monomer which is able to form selective ion channels in target proteins， thus facilitating the transport of chloride and other ions. CLIC4 is believed to have a role in apoptosis and is able to translocate to the nucleus under stress conditions.
