S100A16 belongs to the S100 protein super family containing calcium-binding EF-hand motifs. S100 proteins are cell and tissue specific and are engaged in various intra and extracellular processes through interacting with specific target proteins. The S100A16 expression is astrocyte-specific. S100A16 accumulates within nucleoli and translocates to the cytoplasm in reaction to Ca（2+） stimulation. S100A16 physically interacts with tumor suppressor protein p53 （which is a known inhibitor of adipogenesis） as determined Immunoprecipitation analysis.
