S100A14 belongs to a subfamily of proteins related by EF-hand Ca2+ binding protein superfamily. The extracellular functions of the S100 family include the ability to boost neurite outgrowth， involvement in inflammation， and motility of tumor cells. S100A14 contains 2 EF-hand Ca2+-binding domains， a myristoylation motif， a glycosylation site， and a number of potential protein kinase phosphorylation sites. S100A14 is expressed at high levels in the colon and at moderate levels in the thymus， kidney， liver， small intestine， and lung.
