PHD Finger Protein 5A， also known as PHF5A， is a part of the PHD-finger superfamily and acts as a chromatin-associated protein. PHF5A is a subunit of the splicing factor 3b protein complex which along with splicing factor 3a and a 12S RNA unit， forms the U2 small nuclear ribonucleoproteins complex （U2 snRNP）. The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron’s branch site in a sequence-independent way and anchors the U2 snRNP to the pre-mRNA. PHF5A holds a PHD-finger-like domain which is flanked by highly basic N- and C-termini.
