RBM3 belongs to the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif （RRM） domain. By cold shock and low oxygen tension the expression of this gene is induced. On chromosome 1 a pseudogene exists. Alternate transcriptional splice variants， encoding different isoforms， have been characterized. Diseases associated with RBM3 include vaccinia， andcryptorchidism. GO annotations linked to this gene include RNA binding and ribosomal large subunit binding. An important paralog of this gene is RBMY1J.
