ETS homologous factor （EHF） is a part of the ESE subfamily of Ets transcription factors. Ets factors are an important kind of transcriptional regulators which take part in hema-topoiesis， angiogenesis， organogenesis， oncogenesis and specification of neuronal connectivity. EHF is expressed solely in a subset of epithelial cells， with highest expression noticed in glandular epithelium of the prostate， pancreas， salivary gland and trachea. EHF transactivates the c-Met promoter via 3 high affinity binding sites， which support the notion that EHF contribute to branching morphogenesis.
