Malignant T cell amplified sequence 1 （MCTS1） is an Anti-oncogene which takes part in cell cycle regulation by means of decreasing cell doubling time and encouraging-dependent growth and also by shorting the duration of G1 transit time and G1/S transition. MCTS1 also plays a role as translation enhancer. MCTS1 recruits the density-regulated protein/DENR and binds to the cap complex of the 5’-terminus of mRNAs， thereupon altering the mRNA translation profile； Up-regulates protein levels of BCL2L2， TFDP1， MRE11A， CCND1 and E2F1， while mRNA levels remains constant.
