Receptor activity modifying protein 3 （RAMP3） belongs to the RAMP family of single-transmembrane-domain proteins， named receptor （calcitonin） activity modifying proteins （RAMPs）. RAMP3 is needed to transport calcitonin-receptor-like receptor （CRLR） to the plasma membrane. CRLR acts as either a calcitonin gene-related peptide （CGRP） receptor or an adrenomedullin receptor， depending on which members of the RAMP family are expressed. The existence of RAMP3 effects CRLR to function as an adrenomedullin receptor.
