Neuroblastoma suppressor of tumorigenicity 1 （NBL1） is a part of the evolutionarily conserved CAN （Cerberus and DAN） family of proteins， which contain a domain resembling the CTCK （C-terminal cystine knot-like） motif found in several signaling molecules. NBL1 is a is a tumor suppressor of neuroblastoma and takes part in preventing cells from entering the final stage （G1/S） of the transformation process. NBL1 is produced in small neurons of the dorsal root ganglion. The expression of NBL1 is triggered by MATH-1.
