Killer Cell Lectin-like Receptor Subfamily G， Member 1 （KLRG1） is a member of the killer cell lectin-like receptor （KLR） family， which is a group of transmembrane proteins preferentially expressed in NK cells. Natural killer （NK） cells are lymphocytes which mediate lysis of certain tumor cells and virus-infected cells without previous activation. NK cells can also regulate specific humoral and cell-mediated immunity. The cell surface expression of KLRG1 is up-regulated by MHC class I molecules expression.
