T-cell surface glycoprotein CD3 zeta chain （CD247） is a member of the CD3Z/FCER1G family. CD247 is T-cell receptor zeta， which along with T-cell receptor alpha/beta and gamma/delta heterodimers， and also with CD3-gamma， -delta and -epsilon， creates the T-cell receptor-CD3 complex. The zeta chain has a central role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD247 antigen causes impaired immune response.
