Hemochromatosis （HFE） is a member of the MHC class I family. The Hemochromatosis protein contains 1 Ig-like C1-type （immunoglobulin-like） domain. HFE is a membrane protein， which is similar to MHC class I-type proteins and associates with beta-2 microglobulin （beta2M）. It is assumed that the HFE protein acts to regulate iron absorption by regulating the interaction of the transferrin receptor （TFR） with transferrin. HFE binds to transferrin receptor （TFR） and reduces its affinity for iron-loaded transferrin.
