Endophilin-B2 （SH3GLB2） belongs to the endophilin B subgroup. The endophilins comprise a family of proteins that relates with amphiphysin， synaptojanin and dynamin and are involved in presynaptic vesicle trafficking at nerve terminals.The expression patterns of the endophilins are coherent with their cellular functions at the neuronal synapse. SH3GLB2 is ubiquitously expressed however presents highest levels in brain， adult lung， ovary， and spinal cord.Low levels of SH3GLB2 are found in Down syndrome and reflect brain dysgenesis.
