PHD finger protein 11 （PHF11） is a regulator of TH1-type cytokine gene expression. The decline in PHF11 expression observed with an AD-associated genotype may promote the intense TH2 reactions which characterize numerous allergic individuals. PHF11 is linked with raised total serum IgE levels， asthma and acute atopic dermatitis （AD） in children. Even though PHF11 includes a plant homeodomain， a motif frequently found in transcriptional regulators， PHF11 function of has yet been examined.
