Microfibrillar-associated protein 2 （MFAP2） is an O-glycosylated protein discharged to the extracellular space and the extracellular matrix. MFAP2 connects with biglycan and elastin in a ternary complex. MFAP2 plays a key role in the support and distensibility of the juxtacanalicular region of these collector channels. MFAP2 inhibits LTB-1 binding to fibrillin-1， promotes the phosphorylation of Smad2 thus mediating the consequent extracellular deposition of latent TGFbeta.
