SPRY Domain-Containing SOCS Cox Protein 2 （SPSB2） belongs to a suppressor of cytokine signaling （SOCS） family， and is a member of the subfamily of proteins containing a central SPRY （repeats in splA and RyR） domain and a C-terminal SOCS box. SPSB2 is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. SPSB2 is apparent substrate recognition component of a SCF-like ECS （Elongin BC-CUL2/5-SOCS-box protein） E3 ubiquitin-protein ligase complex that mediates the ubiquitination and ensuing proteasomal degradation of target proteins.
