Transcription Factor B2， Mitochondrial （TFB2M） is an S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. In addition， TFB2M is essential for basal transcription of mitochondrial DNA， most likely via its interaction with POLRMT and TFAM. TFB2M promotes transcription independently of the methyltransferase activity. TFB2M like TFB1M， activates transcription of mitochondrial DNA more effectively， whilst having less methyltransferase activity.
