G antigen family D member 2 （XAGE1A） belongs to the XAGE subfamily， which is a member of the GAGE family. The GAGE genes are expressed various tumors and in a number of fetal and reproductive tissues. XAGE1A contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. XAGE1A is strongly expressed in Ewing’s sarcoma， alveolar rhabdomyosarcoma and normal testis. Due to the expression pattern and the sequence similarity， the XAGE1A protein is also a member of a family of CT （cancer-testis） antigens.
