TSC22 domain family protein 3 （TSC22D3） protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity which initiates the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages， TSC22D3 has a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells， TSC22D3 hinders anti-CD3-induced NFKB1 nuclear translocation. In vitro， TSC22D3 curbs AP1 and NFKB1 DNA-binding activities.
