Methyl-CpG-binding domain protein 3 （MBD3）， belongs to the MBD family of transcriptional repressors. Human proteins MECP2， MBD1， MBD2， MBD3， and MBD4 includes a family of nuclear proteins related by the presence of a methyl-CpG binding domain （MBD） in each protein. Nevertheless， not like the other family members， MBD3 is not capable of binding to methylated DNA. MBD3 is a subunit of the NuRD， a multisubunit complex having nucleosome remodeling and histone deacetylase activities. The predicted MBD3 protein shares 71% and 94% identity with MBD2 （isoform 1） and mouse Mbd3. MBD3 mediates the association of metastasis-associated protein 2 （MTA2） with the core histone deacetylase complex.
