Transgelin 2 （TAGLN2） is one of the earliest markers of differentiated smooth muscle. TAGLN2 contains a calponin like repeat and a calponin-homology （CH） domain. TAGLN2 is downregulated in some transformed cell lines， indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. TAGLN2 also binds actin， causing actin fibers to gel within minutes of binding. The binding of transgelin to actin occurs at a ratio of 1:6 actin monomers.
