TGFB1-induced anti-apoptotic factor 1 （TIAF1） hinders the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD， FADD， and RIPK1. The TIAF1 protein is involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. TIAF1 is not detected in normal kidney and liver. TIAF1 is up-regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells.
