WW domain-binding protein 2 （WBP2） is a steroid hormone receptor coactivator， which contains 1 GRAM domain. The globular WW domain is comprised of 38-40 semiconserved amino acids shared by proteins of various functions including structural， regulatory， and signaling proteins. This domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. WBP2 binds to the WW domain of Yes kinase-associated protein（YAP1） via its PY motifs.
