NDRG2 belongs to the N-myc downregulated gene family that is a part of the alpha/beta hydrolase superfamily. NDRG2 takes part in dendritic and neuronal cell differentiation and outgrowth and is found in large quantities in heart， dendritic cells， brain， salivary gland and skeletal muscle and in small quantities in kidney and liver. In Alzheimer Disease （AD）-affected patients NDRG2 is found in brain lesions and is believed to be related to the progression of AD.
