Vesicle-Associated Membrane Protein 7 （VAMP7） is a member of the synaptobrevin family. VAMP7 is a transmembrane protein， which is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor （SNARE） family. VAMP7 is involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. VAMP7 localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. VAMP7 is essential for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. It is also necessary for calcium regulated lysosomal exocytosis. In addition， VAMP7 is involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Furthermore， VAMP7 is needed for exocytosis of mediators during eosinophil and neutrophil degranulation， and target cell killing by natural killer cells.
