Cluster of Differentiation 244 （CD244/Natural Killer Cell Receptor 2B4） contains 2 Ig-like （immunoglobulin-like） domains. CD244 is a cell surface receptor expressed on natural killer （NK） cells （and some T cells） which mediate non-major histocompatibility complex （MHC） restricted killing. NK-cell and target cells interaction via the CD244 receptor is believed to modulate NK-cell cytolytic activity. CD244 molecules function in eosinophil adhesion and chemotaxis， and have a role in the pathophysiology of allergic rhinitis （AR）.
