Muted homolog （MUTED） is a component of the BLOC-1 complex， a complex which is necessary for normal biogenesis of lysosome-related organelles （LRO）， such as platelet dense granules and melanosomes. The BLOC-1 complex is needed to steer membrane protein cargos into vesicles assembled at cell bodies for release into neurites and nerve terminals. In addition， this complex， along with SNARE proteins， is suggested to be involved in neurite extension. MUTED also interacts with pallidin， dystrobrevin binding protein 1 and CNO/cappuccino. MUTED is ubiquitously expressed with higher levels in the brain， bone marrow， kidney， and liver and lower levels in the skeletal muscle.
