Regulator of G-protein signaling 14 （RGS14） is a member of the regulator of G protein signaling family. RGS14 contains one RGS domain， 2 Raf-like Ras-binding domains （RBDs） and one GoLoco motif. RGS14 reduces the signaling activity of G-proteins by binding， via its GoLoco domain， to specific types of activated， GTP-bound G alpha subunits. RGS14 is a scaffolding protein which integrates G protein and H-Ras/ERK/MAP kinase signaling pathways， thus making it suitably positioned to repress plasticity in CA2 neurons. Since RGS14 is highly enriched in CA2 pyramidal neurons， it has a role in inhibition of both synaptic plasticity at these synapses and hippocampal-based learning and memory.
